Download Episode 2.21: Le piège se referme sur Nolan et son équipe dans The Rookie

Brendan is joined by Ghostbusters super fan Oliver Jones all the way from Birmingham in the UK for an episode 33 years in the making - the release of the brand new Ghostbusters movie set in the continuity of the original films.

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This episode is the first half on one of the most impactful season ends in the history of television. There is an incredible scope of storytelling and foreshadowing going on, all while masterfully expanding our understanding of Angel as a character as well as seeing the origin story of our vampire cast, our knowledge of the Buffyverse, and our big feels that lead up to the heartbreak at the end of the season. We also see very interesting work at expanding our conversation about what happens when you become a vampire and how who you were before and how you are turned dictate much of what type of demon you will become.

OBJECTIVE: To measure the association between orlistat and acute liver injury. DESIGN: Self controlled case series study. SETTING: Population based primary care setting, United Kingdom. PARTICIPANTS: 94,695 patients receiving orlistat and registered in the UK Clinical Practice Research Datalink and linked with Hospital Episode Statistics data between 1999 and 2011. MAIN OUTCOME MEASURE: Relative incidence of acute liver injury comparing periods when patients were receiving orlistat with periods of non-usage. RESULTS: Among 94,695 patients who received orlistat, 988 cases of acute liver injury were identified, with 335 confirmed as definite cases and 653 as probable cases. For all cases an increased incidence of liver injury was detected during the 90 day period before orlistat was first started, with an incidence rate ratio of 1.50 (95% confidence interval 1.10 to 2.06). The incidence remained raised during the first 30 days of treatment (2.21, 1.43 to 3.42), before returning to baseline levels with prolonged treatment. When the risk during the first 90 days of treatment was compared with the 90 days preceding first treatment, the incidence of liver injury was not increased (1.02, 0.67 to 1.56). An analysis restricted to definite cases showed no evidence of an increased risk of liver injury during treatment. CONCLUSION: The incidence of acute liver injury was higher in the periods both immediately before and immediately after the start of orlistat treatment. This suggests that the observed increased risks of liver injury linked to the start of treatment may reflect changes in health status associated with the decision to begin treatment rather than any causal effect of the drug.

Risk score=(former smoker1.47)+(current smoker2.48)+(unknown smoking status1.05)+(asthma0.64)+(1 episode of LRTI0.59)+(>1 episode of LRTI0.80)+(1 episode of cough0.35)+(>1 episode of cough0.57)+(1 episode of dyspnoea1.16)+(>1 episode of dyspnoea1.15)+(wheeze0.62)+(sputum0.40)+(unintended weight loss0.56)+(1 antibiotic course0.29)+(2 antibiotic course0.43)+(>2 antibiotic courses0.59)+(salbutamol1.43)+(prednisolone0.42). 2ff7e9595c